The organization’s head office is located in Bahir Dar, with field offices in Dabat and Debre Markos. It operates across the Amhara region, including North Gondar, East and West/North Gojjam, and Awi Zones, focusing on humanitarian response, life-saving interventions, and trauma management for conflict-affected communities, environmental sanitation, and the documentation of indigenous knowledge.

BEST Ethiopia envisions “an empowered society in Ethiopia that determines its future with dignity.” Its mission is “to work with women, children, youth, disadvantaged groups, and key stakeholders through inclusive and integrated development approaches, enabling communities to take ownership of their development and determine sustainable livelihood options.”